The Bay of Bengal is the largest bay in the world that forms the northeastern part of the Indian Ocean, bordered mostly by the Eastern Coast of India, southern coast of Bangladesh and Sri Lanka to the west and Myanmar and the Andaman and Nicobar Islands (part of India) to the east. The regional management of the Bay of Bengal water area is performed by regional organisations such as ASEAN, SAARC, BIMSTEC and IORA unifying Bay’s coastal states. Nevertheless, differences in political and economic interests of the states, separate conflicts between states and consequences of the pandemic not only challenged the integrity of the regional management but also led to rising insecurity of the Bay of Bengal and fears to navigate in that area. In this article, the authors, in a more detailed way, will disclose existing regional management systems, concerns related to maritime security and give recommendations on how to increase efficiency in collective management of maritime security issues and how the concept of due diligence may play the vital role in the regulation of not only maritime security aspects but also aspects of environmental protection and potential transition to the blue economy.